As filed with the Securities and Exchange Commission on November 25, 2019

Registration Nos. 333-222756

333-227571

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

_____________________

POST-EFFECTIVE AMENDMENT NO. 2

TO

FORM S–1

ON FORM S‑3

REGISTRATION STATEMENT

Under

The Securities Act of 1933

_____________________

_____________________

888 Prospect Street, Suite 210

La Jolla, CA 92037

(760) 943-1689

(Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices)

_____________________

Gregory D. Gorgas

Chief Executive Officer and President

888 Prospect Street, Suite 210

La Jolla, CA 92037

Telephone: (760) 943-1689

(Name, address, including zip code, and telephone number, including area code, of agent for service)

_____________________

Copies to:

 Martin J. Waters

Wilson Sonsini Goodrich & Rosati, P.C.

12235 El Camino Real

San Diego, CA 92130

Telephone: (858) 350-2300

Facsimile: (858) 350-2399

From time to time after this Registration Statement becomes effective.

(Approximate date of commencement of proposed sale to the public)

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: o

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: x

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o

If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o

If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. o

If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. o

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer”, “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act. (Check one):

If an emerging growth company, indicate by check mark if the Registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided to Section 7(a)(2)(B) of the Securities Act. o

The Registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(c) of the Securities Act of 1933, as amended, or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(c), may determine.

EXPLANATORY NOTE

The Registrant is filing a single prospectus in this Registration Statement pursuant to Rule 429 under the Securities Act, in order to satisfy the requirements of the Securities Act and the rules and regulations thereunder for this offering. Pursuant to Rule 429 under the Securities Act of 1933, the prospectus included in this Registration Statement is a combined prospectus relating to (i) Registration Statement No. 333-222756 previously filed by the Registrant on Form S-1 on January 29, 2018 and declared effective by the Securities and Exchange Commission on May 29, 2018 and which related to the resale of up to shares of common stock of the Registrant (including shares issuable upon exercise of warrants held by certain selling stockholders) from time to time by the selling stockholders named therein (the “First Registration Statement”) and (ii) Registration Statement No. 333-227571 previously filed by the Registrant on Form S-1 on September 27, 2018 and declared effective by the Securities and Exchange Commission on October 5, 2018, and which related to the resale of shares of common stock of the Registrant (including shares issuable upon exercise of warrants held by certain selling stockholders) from time to time by the selling stockholders named therein (the “Second Registration Statement”).

This Post-Effective Amendment to Form S-1 on Form S-3 constitutes a Post-Effective Amendment No.  2 to the First Registration Statement and the Second Registration Statement and is being filed by the Registrant to convert the First Registration Statement and Second Registration Statement into a registration statement on Form S-3. This Registration Statement contains an updated prospectus relating to the offering and sale of the shares that were registered for resale on the First Registration Statement and the Second Registration Statement. Such post-effective amendments shall hereafter become effective concurrently with the effectiveness of this Registration Statement in accordance with Section 8(c) of the Securities Act of 1933, as amended.

The information in this prospectus is not complete and may be changed. The selling stockholders may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

PROSPECTUS

Artelo Biosciences, Inc.

Common Stock

____________________

Offered by Selling Stockholders

This prospectus relates to the disposition from time to time of up to 899,183 shares of our common stock (including up to 495,306 shares issuable upon exercise of warrants), which are held by the selling stockholders named in this prospectus. We will not receive any of the proceeds from the sale of our common stock by the selling stockholders.

The selling stockholders identified in this prospectus, or their permitted transferees or other successors-in-interest, may offer the shares from time to time through public or private transactions at prevailing market prices, at prices related to prevailing market prices, or at privately negotiated prices. We provide additional information about how the selling stockholders may sell their shares of common stock in the section entitled “Plan of Distribution” beginning on page 11 of this prospectus. We will not be paying any underwriting discounts or selling commissions in connection with any offering of common stock under this prospectus.

Our common stock and public warrants are  trading on the Nasdaq Capital Market (“Nasdaq”) under the symbols “ARTL” and “ARTLW,” respectively. The last reported sale price of our common stock as reported on Nasdaq on November 22, 2019 was $2.83 per share.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2019.

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		Page
FORWARD LOOKING STATEMENTS			vi
PROSPECTUS SUMMARY			1
RISK FACTORS			6
USE OF PROCEEDS			7
SELLING STOCKHOLDERS			8
PLAN OF DISTRIBUTION			11
LEGAL MATTERS			13
EXPERTS			13
WHERE YOU CAN FIND ADDITIONAL INFORMATION			13
INFORMATION INCORPORATED BY REFERENCE			13

 

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ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the United States Securities and Exchange Commission, or the SEC, using a “shelf” registration process. Under this shelf process, the selling stockholders may from time to time sell up to an aggregate amount of 899,183 shares of our common stock (including up to 495,306 shares issuable upon exercise of warrants) in one or more offerings. You should not assume that the information contained in this prospectus is accurate on any date subsequent to the date set forth on the front cover of this prospectus or that any information we have incorporated by reference is correct on any date subsequent to the date of the document incorporated by reference, even though this prospectus is delivered or shares of common stock are sold or otherwise disposed of on a later date. It is important for you to read and consider all information contained in this prospectus, including the documents incorporated by reference therein, in making your investment decision. You should also read and consider the information in the documents to which we have referred you under the captions “Where You Can Find Additional Information” and “Information Incorporated by Reference” in this prospectus.

We have not authorized any dealer, salesman or other person to give any information or to make any representation other than those contained or incorporated by reference in this prospectus. You must not rely upon any information or representation not contained or incorporated by reference in this prospectus. This prospectus does not constitute an offer to sell or the solicitation of an offer to buy any of our shares of common stock other than the shares of our common stock covered hereby, nor does this prospectus constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction. Persons who come into possession of this prospectus in jurisdictions outside the United States are required to inform themselves about, and to observe, any restrictions as to the offering and the distribution of this prospectus applicable to those jurisdictions.

This prospectus incorporates by reference market data, industry statistics and other data that have been obtained from, or compiled from, information made available by third parties. We have not independently verified their data.

Except where the context otherwise requires or where otherwise indicated, the terms “we,” “us,” “our,” “Artelo Biosciences,” “Artelo” and “the company” refer to Artelo Biosciences, Inc., a Nevada corporation, and its consolidated subsidiaries. References to the “selling stockholders” refer to the stockholders listed herein under the heading “Selling Stockholders” and each of their donees, pledgees, transferees or other successors-in-interest.

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Forward-Looking Statements

The information in this Registration Statement on Form S-3 and the information incorporated herein by reference, include forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements are based on current expectations and beliefs and involve numerous risks and uncertainties that could cause actual results to differ materially from expectations. These forward-looking statements should not be relied upon as predictions of future events as we cannot assure you that the events or circumstances reflected in these statements will be achieved or will occur. When used in this report, the words “believe,” “may,” “could,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “indicate,” “seek,” “should,” “would” and similar expressions are intended to identify forward-looking statements, though not all forward-looking statements contain these identifying words. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements.

These statements reflect our current views with respect to future events and are based on assumptions and subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. We discuss many of these risks in greater detail in our reports filed from time to time under the Securities Act and/or the Exchange Act, including the risks identified under the heading “Risk Factors” in our most recent Annual Report on Form 10-K and our most recent Quarterly Report on Form 10-Q which are incorporated by reference into this prospectus in their entirety. We encourage you to read these filings as they are made. Also, these forward-looking statements represent our estimates and assumptions only as of the date of the document containing the applicable statement.

You should read this prospectus, the documents incorporated by reference herein, and any prospectus supplement or free writing prospectus that we have authorized for use in connection with this offering completely and with the understanding that our actual future results may be materially different from what we expect. We qualify all of the forward-looking statements in the foregoing documents by these cautionary statements.

You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. Moreover, except as required by law, we undertake no obligation to update publicly any forward-looking statements for any reason after the date of this prospectus to conform these statements to actual results or to changes in our expectations. Thus, you should not assume that our silence over time means that actual events are bearing out as expressed or implied in such forward-looking statements.

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Our second in-licensed program is a platform of small-molecule inhibitors targeting fatty acid binding protein 5 (“FABP5”), based upon scientific developments achieved at Stony Brook University (“SBU”) which we have designated ART26.12. To date, SBU has received nearly $4 million in funding from the National Institutes of Health to begin developing these candidates. Fatty acid binding proteins (“FABPs”) are attractive therapeutic targets, however, their high degree of similarity among the various types has proven challenging to the creation of drugs targeting specific FABPs. FABP5 is believed to specifically target and regulate one of the body's endogenous cannabinoids, anandamide (“AEA”). While searching for a FABP5 inhibitor to regulate AEA, we believe researchers at SBU discovered the chemistry for creating a highly specific and potent small molecule inhibitor for FABP5. In addition to its potential as an endocannabinoid modulator, FABP5 is also an attractive target for cancer drug development. Large amounts of human clinical epidemiological and animal model data support FABP5 as a well validated oncology therapeutic target, especially for triple negative breast cancer and castration-resistant prostate cancer. We licensed exclusive world-wide rights to these inhibitors from SBU. The program is in the final stages of lead optimization, and we plan to initiate regulatory enabling studies thereafter. We anticipate clinical studies in cancer can begin in 2021.   We are developing our product candidates in accordance with traditional drug development standards and plan to make them available to the general public via prescription or physician orders only after obtaining marketing authorization from a regulatory authority, such as the U.S. Food and Drug Administration (the “FDA”). Our management team has experience developing and commercializing ethical pharmaceutical products, including several first-in-class therapeutics. Based upon our current management’s capabilities and the future talent we may attract, we expect to retain rights to internally develop and commercialize products, however, we may seek collaborations with partners in the biopharmaceutical industry when that strategy serves to maximize value for our stockholders.   Background     The ECS is composed of cannabinoid receptors, endogenous receptor ligands (“endocannabinoids”) and their associated transporter mechanisms, as well as enzymes responsible for the synthesis and degradation of endocannabinoids, and has emerged as a considerable target for pharmacotherapy approaches of numerous human diseases. As a widespread modulatory system, the ECS plays important roles in the central nervous system (the “CNS”), development, synaptic plasticity, and the response to endogenous and environmental factors.   The modulation of the ECS can be effected by using selective or non-selective agonists, partial agonists, inverse agonists, and antagonists of the cannabinoid receptors, CB1 and CB2. The CB1 receptor is distributed in brain areas associated with motor control, emotional responses, motivated behavior and energy homeostasis. In the periphery, CB1 is ubiquitously expressed in the adipose tissue, pancreas, liver, gastrointestinal tract, skeletal muscles, heart and the reproductive system. The CB2 receptor is mainly expressed in the immune system regulating its functions, and is upregulated in response to tissue stress or damage in most cell types. The ECS is therefore involved in pathophysiological conditions in both the central and peripheral tissues.   The actions of endogenous ligands can be enhanced or attenuated by targeting mechanisms that are associated with their transport within the cellular and extra cellular matrix as well as their synthesis and breakdown. Small molecule chemical modulators of the ECS can be derived from naturally occurring cannabinoids, can be synthetic cannabinoids, or can be completely new chemical entities. We plan to develop approaches within our portfolio that address receptor binding and endocannabinoid transport modulation using only small molecule synthetic new chemical entities. Future approaches may also involve targeting synthesis or breakdown enzymes.   ECS targeting cannabinoid-based medicines are already approved and used to treat numerous medical conditions. The ECS is further implicated in many disease states within the peer reviewed literature including conditions which involve the regulation of food intake, central nervous system, pain, cardiovascular, gastrointestinal, immune and inflammation, behavioral, antiproliferative and reproductive functions. These areas of ECS pathophysiology are aligned with our therapeutic areas of focus: pain, inflammation, anorexia, cardiovascular, and cancer.

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	Implications of being an Emerging Growth Company
	We qualify as an “emerging growth company” as defined in the Jumpstart Our Business Startups Act of 2012, or the JOBS Act, enacted in April 2012. An “emerging growth company” may take advantage of reduced reporting requirements that are otherwise applicable to public companies. These provisions include, but are not limited to:
	·	being permitted to present only two years of audited financial statements and only two years of “Selected Financial Data” and related “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in this prospectus;
	·	not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, as amended;
	·	reduced disclosure obligations regarding executive compensation in our periodic reports, proxy statements and registration statements; and
	·	exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously approved.
	We may use these provisions until the last day of our fiscal year ending August 2020. However, if certain events occur prior to the end of such period, including if we become a “large accelerated filer,” our annual gross revenue exceeds $1.07 billion or we issue more than $1.0 billion of non-convertible debt in any three-year period, we will cease to be an emerging growth company prior to the end of such period.
	We have elected to take advantage of certain of the reduced disclosure obligations in the registration statement of which this prospectus is a part and may elect to take advantage of other reduced reporting requirements in future filings. As a result, the information that we provide to our stockholders may be different than you might receive from other public reporting companies in which you hold equity interests.
	In addition, the JOBS Act provides that an emerging growth company can take advantage of an extended transition period for complying with new or revised accounting standards, delaying the adoption of these accounting standards until they would apply to private companies. We have elected to avail ourselves of this exemption and, therefore, we are not subject to the same new or revised accounting standards as other public companies that are not emerging growth companies.

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RISK FACTORS

Before you invest in our securities, you should be aware that our business faces numerous financial and market risks, including those described below, as well as general economic and business risks. Our securities are speculative, and you should not make an investment in Artelo Biosciences unless you can afford to bear the loss of your entire investment. Prior to making a decision about investing in our common stock, you should carefully consider the risks, uncertainties and assumptions discussed under Item 1A, “Risk Factors,” in our Annual Report on Form 10-K for the fiscal year ended August 31, 201 9 , as updated by our subsequent filings with the Securities and Exchange Commission, or the SEC, under the Securities Exchange Act of 1934, as amended, or the Exchange Act, which are incorporated herein by reference, together with the information in this prospectus and any other information incorporated by reference into this prospectus. Before you decide whether to invest in our securities, you should carefully consider these risks and uncertainties, together with all of the other information included in or incorporated by reference into this prospectus. The risks and uncertainties identified are not the only risks and uncertainties we face. If any of the material risks or uncertainties that we face were to occur, you could lose part or all of your investment.

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USE OF PROCEEDS

We will not receive any of the proceeds from the sale of the common stock by the selling stockholders named in this prospectus; however, to the extent the selling stockholders exercise the warrants, we will receive the aggregate exercise price from the exercise of the warrants. All proceeds from the resale of the shares of our common stock offered by this prospectus will belong to the selling stockholders identified in this prospectus under “Selling Stockholders.”

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SELLING STOCKHOLDERS

The shares may be offered by the selling stockholders or by pledges, donees, transferees or other successors in interest that receive such shares as a gift or through a private sale or transfer. We may amend or supplement this prospectus from time to time to update information provided in the table.

Selling Stockholder	Shares Beneficially	Number of	Shares Beneficially	Percentage of Shares
	Owned Prior to	Shares Being	Owned After	Beneficially Owned
	Offering	Offered	Offering	After Offering (1)
Alinga Capital Fund, L.P. (2)	113,125	28,750	37,500	1.10%
Andrew Yates (3)	3,367	3,367	0	*
ATGC Partners, LLC (4)	3,850	3,850	0	*
Barry Collins (5)	23,735	23,735	0	*
Bernard Bradley (6)	9,375	9,375	0	*
Brady Costello (7)	3,333	3,333	0	*
Brett Nesland (8)	37,500	37,500	0	*
Brian Murphy (9)	7,000	3,333	3,667	*
Candida Del Rosario-Boardman (10)	1,000	1,000	0	*
CB1 Wellness Master Fund LP (11)	32,500	32,500	0	*
Charles M. Natcher (12)	2,500	2,500	0	*
Charles W. Howe (13)	10,000	10,000	0	*
Christopher A. Bellamy (14)	3,333	3,333	0	*
Colum Whelan (15)	3,333	3,333	0	*
David Kaufman (16)	10,000	10,000	0	*
David Moss (17)	249,057	81,731	167,326	4.90%
Don Stangle (18)	60,049	60,049	0	*
Duncan Ley (19)	3,333	3,333	0	*
Eric Baum (20)	15,833	15,833	0	*
Evan Duggan (21)	3,125	3,125	0	*
Five Points Capital Management LLC (22)	17,500	17,500	0	*
GammaQ LLC (23)	76,923	76,923	0	*
Gregory D. Gorgas (24)	257,019	37,019	220,000	6.44%
Jamie Sherry (25)	4,624	4,624	0	*
Jeffery Bergau (26)	5,750	5,750	0	*
John Brady (27)	14,615	11,282	3,333	*
Jon Smith (28)	19,040	19,040	0	*
Justin R. Hone (29)	3,846	3,846	0	*
Loretta Kelly (30)	5,000	5,000	0	*
Malibu Investments, Ltd. (31)	7,693	7,693	0	*
Mark Sockell (32)	6,667	6,667	0	*
Matt Matthews (33)	4,500	4,500	0	*
Michael Donnelly (34)	5,000	5,000	0	*
Michael Hay (35)	8,250	8,250	0	*
Mosetta Nominees (36)	7,179	7,179	0	*
NEOMED Institute (37)	76,297	15,000	61,297	1.79%
Nicholas O’Connor (38)	1,381	1,381	0	*
Patrick Lawlor (39)	10,000	10,000	0	*
Patton Acquisitions Ltd. (40)	3,333	3,333	0	*
Paul Quilkey (41)	113,125	46,875	37,500	1.10%
Prodigious Wealth Limited (42)	125,000	125,000	0	*
Rachel Tubridy (43)	2,500	2,500	0	*
Robert Emmet Bourke (44)	19,575	19,575	0	*
Robert Kelly (45)	15,011	7,693	7,318	*
Robert Morlock (46)	20,432	20,432	0	*
Rudi Neuman (47)	4,413	4,413	0	*
Shawn Bohannan (48)	9,615	9,615	0	*
Steven M. Bathgate (49)	5,000	5,000	0	*
The Colm Egan Pension Fund (50)	7,495	7,495	0	*
Thomas William Corbett (51)	5,144	5,144	0	*
Value of Insight Consulting, Inc. (52)	27,500	27,500	0	*
Windsor Wealth Management (53)	1,563	1,563	0	*
WOCO Limited (54)	7,179	7,179	0	*
WS Investment Company, LLC (55)	19,232	19,232	0	*
Total		899,183

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(1)	Based upon 3,426,276 shares of common stock outstanding as of the close of business on November 21, 2019 (the “Measurement Date”) in accordance with Rule 13d-3 under the Securities Exchange Act of 1934.
(2)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 28,750 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase, and 23,437 shares of our common stock and warrant(s) to purchase a total of 23,438 shares of our common stock held by Paul Quilkey, a principal of Alinga Capital Fund, L.P.
(3)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,684 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(4)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,925 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(5)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 11,869 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(6)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 4,688 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(7)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,667 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(8)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 25,000 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(9)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 3,501 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(10)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 500 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(11)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 16,250 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(12)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,250 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(13)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 5,000 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(14)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,667 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(15)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,667 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(16)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 5,000 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(17)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 40,866 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(18)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 53,750 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(19)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,667 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(20)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 7,917 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(21)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,563 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(22)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 8,750 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(23)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 38,462 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(24)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 18,510 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(25)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 2,313 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(26)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 2,875 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(27)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,667 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(28)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 9,520 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.

   

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(29)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,923 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(30)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 2,500 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(31)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 7,693 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(32)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 3,334 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(33)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 2,250 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(34)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 5,000 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(35)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 4,125 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(36)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 3,590 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(37)	Shares beneficially owned prior to offering do not include any warrant(s) to purchase shares of our common stock.
(38)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 691 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(39)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 5,000 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(40)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,667 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(41)	Shares beneficially owned prior to offering includes 23,437 shares of our common stock and warrant(s) to purchase a total of 23,438 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase and warrant(s) to purchase a total of 28,750 shares of our common stock held by Alinga Capital Fund, L.P
(42)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 62,500 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(43)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 1,250 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(44)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 9,788 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(45)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 6,287 shares of our common stock, , of which 3,847 warrants are fully exercisable for up to five (5) years from the date of purchase and 2,440 warrants are fully exercisable for up to three (3) years from the date of purchase.
(46)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 10,217 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(47)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 2,207 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(48)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 4,808 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(49)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 5,000 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(50)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 3,748 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(51)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 2,573 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(52)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 13,750 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(53)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 782 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(54)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 3,590 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.
(55)	Shares beneficially owned prior to offering includes warrant(s) to purchase a total of 9,616 shares of our common stock, which are fully exercisable for up to five (5) years from the date of purchase.

PLAN OF DISTRIBUTION

The selling stockholders and any of their pledgees, assignees and successors-in-interest may, from time to time, sell any or all of their shares of common stock on any stock exchange, market or trading facility on which the shares are traded or in private transactions. As of the date of this prospectus, our common stock is trading on Nasdaq and, for so long as our common stock continues trading on that exchange , we expect that sales made in the Nasdaq market will likely be effected on that exchange . As of November 22, 2019, the last reported closing price for our common stock on Nasdaq was $2.83 per share, and as such represented the market price for our common stock as of that date. Sales of the common stock to be registered hereunder could be made at prevailing market prices at the time of the sale, at fixed prices, at negotiated prices, or at varying prices determined at the time of sale. As a result, we cannot know the price at which any of our common stock to be registered hereunder may ultimately be sold by the holders thereof. Shares of our common stock are currently trading on the Nasdaq under the symbol ARTL. The selling stockholders may use any one or more of the following methods when disposing of shares or interests therein:

·	ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers;
·	block trades in which the broker-dealer will attempt to sell the shares as agent, but may position and resell a portion of the block as principal to facilitate the transaction;
·	purchases by a broker-dealer as principal and resale by the broker-dealer for its account;
·	an exchange distribution in accordance with the rules of the applicable exchange;
·	privately negotiated transactions;
·	short sales effected after the date the registration statement of which this prospectus is a part is declared effective by the SEC;
·	through the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise;
·	broker-dealers may agree with the selling stockholders to sell a specified number of such shares at a stipulated price per share;
·	a combination of any such methods of sale; and
·	any other method permitted by applicable law.

 

The selling stockholders may, from time to time, pledge or grant a security interest in some or all of the shares of common stock owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the shares of common stock, from time to time, under this prospectus, or under an amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act amending the list of selling stockholders to include the pledgee, transferee or other successors in interest as selling stockholders under this prospectus. The selling stockholders also may transfer the shares of common stock in other circumstances, in which case the transferees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus.

In connection with the sale of our common stock or interests therein, the selling stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the common stock in the course of hedging the positions they assume. The selling stockholders may also sell shares of our common stock short and deliver these securities to close out their short positions, or loan or pledge the common stock to broker-dealers that in turn may sell these securities. The selling stockholders may also enter into option or other transactions with broker-dealers or other financial institutions or the creation of one or more derivative securities which require the delivery to such broker-dealer or other financial institution of shares offered by this prospectus, which shares such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction).

The aggregate proceeds to the selling stockholders from the sale of the common stock offered by them will be the purchase price of the common stock less discounts or commissions, if any. Each of the selling stockholders reserves the right to accept and, together with their agents from time to time, to reject, in whole or in part, any proposed purchase of common stock to be made directly or through agents. We will not receive any of the proceeds from this offering. Upon any exercise of the warrants by payment of cash, however, we will receive the exercise price of the warrants.

The selling stockholders also may resell all or a portion of the shares in open market transactions in reliance upon Rule 144 under the Securities Act, provided that they meet the criteria and conform to the requirements of that rule.

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The selling stockholders and any underwriters, broker-dealers or agents that participate in the sale of the common stock or interests therein may be “underwriters” within the meaning of Section 2(11) of the Securities Act. Any discounts, commissions, concessions or profit they earn on any resale of the shares may be underwriting discounts and commissions under the Securities Act. Selling stockholders who are “underwriters” within the meaning of Section 2(11) of the Securities Act will be subject to the prospectus delivery requirements of the Securities Act.

To the extent required, the shares of our common stock to be sold, the names of the selling stockholders, the respective purchase prices and public offering prices, the names of any agents, dealer or underwriter, any applicable commissions or discounts with respect to a particular offer will be set forth in an accompanying prospectus supplement or, if appropriate, a post-effective amendment to the registration statement that includes this prospectus.

In order to comply with the securities laws of some states, if applicable, the common stock may be sold in these jurisdictions only through registered or licensed brokers or dealers. In addition, in some states the common stock may not be sold unless it has been registered or qualified for sale or an exemption from registration or qualification requirements is available and is complied with.

We have advised the selling stockholders that the anti-manipulation rules of Regulation M under the Exchange Act may apply to sales of shares in the market and to the activities of the selling stockholders and their affiliates. In addition, to the extent applicable we will make copies of this prospectus (as it may be supplemented or amended from time to time) available to the selling stockholders for the purpose of satisfying the prospectus delivery requirements of the Securities Act. The selling stockholders may indemnify any broker-dealer that participates in transactions involving the sale of the shares against certain liabilities, including liabilities arising under the Securities Act.

We have agreed to indemnify the selling stockholders against liabilities, including liabilities under the Securities Act and state securities laws, relating to the registration of the shares offered by this prospectus.

We have agreed with the selling stockholders to keep the registration statement of which this prospectus constitutes a part effective until the earlier of (1) such time as all of the shares covered by this prospectus have been disposed of pursuant to and in accordance with the registration statement or (2) the date on which all of the shares may be sold without restriction pursuant to Rule 144 of the Securities Act.

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LEGAL MATTERS

Selected legal matters with respect to the validity of the securities offered by this prospectus will be passed upon for us by Fennemore Craig, P.C., Reno, Nevada.

EXPERTS

The consolidated financial statements of Artelo Biosciences, Inc. as of August 31, 2019 and 2018  and for each of the two years ended August 31, 2019 and 2018 have been incorporated by reference herein and in the registration statement have been so included in reliance on the report (which includes an explanatory paragraph relating to Artelo’s ability to continue as a going concern as described in Note 3 to the financial statements) of MaloneBailey, LLP, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.

WHERE YOU CAN FIND ADDITIONAL INFORMATION

We file annual, quarterly and other reports, proxy statements and other information with the SEC. Our SEC filings are available to the public over the Internet at the SEC’s website at http://www.sec.gov. Our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, including any amendments to those reports, and other information we file with or furnish to the SEC pursuant to Section 13(a) or 15(d) of the Exchange Act can also be accessed free of charge at our website at http://www.artelobio.com. Such information is made available on our website as soon as reasonably practicable after we electronically file it with or furnish it to the SEC. Information contained on our website is not part of this prospectus.

INFORMATION INCORPORATED BY REFERENCE

The SEC allows us to “incorporate by reference” into this prospectus the information we file with the SEC, which means we may disclose important information to you by referring you to other documents we file separately with the SEC. The information we incorporate by reference is considered a part of this prospectus. We hereby incorporate by reference the following documents previously filed with the SEC:

	·	Artelo’s Annual Report on Form 10-K for the fiscal year ended August 31, 2019 filed on November 25 , 201 9
	·	Artelo’s Current Reports on Form 8-K filed on September 6, 2019 and November 15, 2019; and
	·	Artelo’s description of its common stock set forth in the registration statement on Form 8-A registering the common stock under Section 12 of the Exchange Act filed on June 21, 2019, including any amendments or reports filed for purposes of updating such description.

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Any information in the foregoing documents will automatically be deemed to be modified or superseded to the extent that information in this prospectus modifies or replaces such information. We also incorporate by reference any future filings (other than information furnished under Item 2.02 or Item 7.01 of Form 8-K and exhibits filed on such form that are related to such items) made with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act until we file a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold. Information in such future filings shall be deemed to update and supplement the information provided in this prospectus, and any statements in such future filings will automatically be deemed to modify and supersede any information in any document we previously filed with the SEC that is incorporated or deemed to be incorporated herein by reference to the extent that the statements in the later filed document modify or replace such earlier statements.

You may obtain from us copies of the documents incorporated by reference in this prospectus, at no cost, by requesting them in writing or by telephone at:

Artelo Biosciences, Inc.

888 Prospect Street, Suite 210

La Jolla, California 92037

(760) 943-1689

You should rely only on the information incorporated by reference or provided in this prospectus. We have not authorized anyone to provide you with different information. You should not assume that the information in this prospectus is accurate as of any date other than the date on the front of this document. Any statement contained in a document incorporated in this prospectus will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus modifies or supersedes that statement. Any statement that is modified or superseded will not constitute a part of this prospectus, except as modified or superseded.

Copies of the documents incorporated by reference may also be found on our website at www.artelobio.com. Except with respect to the documents expressly incorporated by reference above which are accessible at our website, the information contained on our website is not a part of, and should not be construed as being incorporated by reference into, this prospectus.

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899,183 Shares of Common Stock

Offered by Selling Stockholders

Artelo Biosciences, Inc.

Common Stock

_______________________________

PROSPECTUS

_______________________________

  , 2019

PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution.

The following table sets forth expenses in connection with the issuance and distribution of the securities being registered. All amounts shown are estimated.

We have agreed to pay the foregoing expenses and we will not be seeking reimbursement from the selling stockholders.

Item 15. Indemnification of Directors and Officers.

The Company’s Articles of Incorporation and Bylaws provide that, to the fullest extent permitted by the laws of the State of Nevada, any officer or director of the Company, who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he/she is or was or has agreed to serve at the request of the Corporation as a director, officer, employee or agent of the Corporation, or while serving as a director or officer of the Corporation, is or was serving or has agreed to serve at the request of the Corporation as a director, officer, employee or agent (which, for purposes hereof, shall include a trustee, partner or manager or similar capacity) of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, or by reason of any action alleged to have been taken or omitted in such capacity. For the avoidance of doubt, the foregoing indemnification obligation includes, without limitation, claims for monetary damages against Indemnitee to the fullest extent permitted under Section 78.7502 of the Nevada Revised Statutes as in existence on the date hereof.

The indemnification provided shall be from and against expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by Indemnitee or on Indemnitee’s behalf in connection with such action, suit or proceeding and any appeal therefrom, but shall only be provided if Indemnitee acted in good faith and in a manner Indemnitee reasonably believed to be in or not opposed to the best interests of the Corporation, and, with respect to any criminal action, suit or proceeding, had no reasonable cause to believe Indemnitee’s conduct was unlawful.

In the case of any threatened, pending or completed action or suit by or in the right of the Corporation to procure a judgment in its favor by reason of the fact that he/she is or was a director, officer, employee or agent of the Corporation, or while serving as a director or officer of the Corporation, is or was serving or has agreed to serve at the request of the Corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, no indemnification shall be made in respect of any claim, issue or matter as to which Indemnitee shall have been adjudged to be liable to the Corporation unless, and only to the extent that, the Nevada courts or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, Indemnitee is fairly and reasonably entitled to indemnity for such expenses which the Nevada courts or such other court shall deem proper.

  

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The termination of any action, suit or proceeding by judgment, order, settlement, conviction, or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a presumption that he/she did not act in good faith and in a manner which Indemnitee reasonably believed to be in or not opposed to the best interests of the Corporation, and, with respect to any criminal action or proceeding, had reasonable cause to believe that Indemnitee’s conduct was unlawful.

To the extent that indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling our company pursuant to the foregoing provisions, we have been informed that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable. If a claim for indemnification against such liabilities (other than the payment by us of expenses incurred or paid by a director, officer or controlling person of our company in the successful defense of any action, suit or proceeding) is asserted by any of our directors, officers or controlling persons in connection with the securities being registered, we will, unless in the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by us is against public policy as expressed in the Securities Act and will be governed by the final adjudication of that issue.

Item 16. Exhibits.

(a) Exhibits.

The exhibits to the registration statement are listed in the Exhibit Index attached hereto and incorporated by reference herein.

Item 17. Undertakings.

 

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provided, however, that paragraphs (l)(i), (l)(ii) and (l)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended, that are incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the registration statement

 

(2)	That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
(3)	To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(4)	That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser:

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on  November 25 , 2019.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated:

  

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EXHIBIT INDEX

#	Management contracts or compensatory plans, contracts or arrangements.

+	Certain portions of this exhibit have been omitted.

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